Asymmetric expression of antivin/lefty1 in the early chick embryo
نویسندگان
چکیده
Mammalian lefty and zebrafish antivin, highly related to lefty, are shown to be expressed asymmetrically and involved in the specification of the left body side of early embryos. We isolated a chick homologue of the antivin/lefty1 cDNA and studied its expression pattern during early chick development. We found that antivin/lefty1 is expressed asymmetrically on the left side of the prospective floorplate, notochord and lateral plate mesoderm of the chick embryo.
منابع مشابه
Chick CFC controls Lefty1 expression in the embryonic midline and nodal expression in the lateral plate.
Members of the EGF-CFC family of proteins have recently been implicated as essential cofactors for Nodal signaling. Here we report the isolation of chick CFC and describe its expression pattern, which appears to be similar to Cfc1 in mouse. During early gastrulation, chick CFC was asymmetrically expressed on the left side of Hensen's node as well as in the emerging notochord, prechordal plate, ...
متن کاملConserved requirement for EGF-CFC genes in vertebrate left-right axis formation.
Specification of the left-right (L-R) axis in the vertebrate embryo requires transfer of positional information from the node to the periphery, resulting in asymmetric gene expression in the lateral plate mesoderm. We show that this activation of L-R lateral asymmetry requires the evolutionarily conserved activity of members of the EGF-CFC family of extracellular factors. Targeted disruption of...
متن کاملAntivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.
Mesoderm induction and patterning are mediated by members of the TGFbeta superfamily. We have isolated a novel zebrafish member, antivin, that structurally is highly related to mouse lefty. Overexpression of antivin completely abolishes mesoderm induction at blastula stage, yet resultant embryos develop well-patterned epidermal and neural derivatives. The mesoderm-inhibiting activity of antivin...
متن کاملS10-02 Left/right asymmetric neuronal fate specification in Caenorhabditis elegans
How and at what stage of development are the axes of the body determined? The left–right axis of the mouse embryo is generated de novo at embryonic day (E) 8.0 by utilizing three preexisting positional cues. One of the pre-existing cues is the A–P information, which is represented by the posterior tilt of node cilia. I will discuss the mechanism as to how node cilia are tilted by incorporating ...
متن کاملBMP signaling positively regulates Nodal expression during left right specification in the chick embryo.
Exogenous application of BMP to the lateral plate mesoderm (LPM) of chick embryos at the early somite stage had a positive effect on Nodal expression. BMP applications into the right LPM were followed by a rapid activation of Nodal, while applications into the left LPM resulted in expansion of the normal domain of Nodal expression. Conversely, blocking of BMP signaling by Noggin in the left LPM...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Mechanisms of Development
دوره 90 شماره
صفحات -
تاریخ انتشار 2000